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The drug is indicated as a single agent for the treatment of patients with locally advanced or metastatic non-squamous, non-small cell lung cancer after prior chemotherapy for the maintenance treatment of patients with locally advanced or metastatic non-squamous, non-small cell lung cancer whose disease has not progressed after four cycles of platinum based first-line chemotherapy in combination with cisplatin therapy for the initial treatment of patients with locally advanced or metastatic non-squamous, non-small cell lung cancer in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma, whose disease is unresectable or who are otherwise not candidates for curative surgery

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They form a highly dynamic entity, continuously transmitting signals to the individual components that undergo a series of regulations to enhance or modulate the integrity of the intestinal barrier