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22, 23 In children with GHD, changes were identified in MAPK- and GRB2/SOS-mediated signaling pathways (e.g., IGF-I) associated with carriage of the A allele ( GRB2 decreased expression −1.2-fold, SOS1 increased expression +1.2-fold)
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Upon expert review, 20% of initial visits could have been avoided, of which 33% deemed avoidable with an urgent visit in hepatology, urgent paracentesis (24%), improved medical management at home (23%) and/or non-emergent weekend/holiday services (16%)