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Although the evidence is compelling that cysteine S -conjugate β-lyase reactions contribute to the nephrotoxicity of DCVC and other cysteine S -conjugates derived from halogenated alkenes, as noted earlier, the sulfoxides of the cysteine S -conjugate and mercapturates may be even more toxic than the cysteine S -conjugate (Lash et al., 1994, Lash et al., 2003, Werner et al., 1996)

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Furthermore, individuals who are chronically exposed to low-pressure hypoxic environments at high altitudes, or who climb mountains, travel to high plateaus, or fly airplanes, are potentially at risk for cognitive decline and neurodegeneration (Prasad et al., 2013