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An estimated 5–10% of E2/E2 individuals present with type III hyperlipoproteinemia (HLP-III), and E2 carriage has been linked to a higher risk of melanoma 38 , age-related macular degeneration 39 and even some neurological disorders such as posttraumatic stress disorder 40 and progressive supranuclear palsy 41

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One limitation of this study is that the data were collected in vitro, rather than in vivo