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29 Research using the cannabinoid receptor agonist CB2- β-caryophyllene (BCP) in animal models has shown that OXI therapy results in dysregulation of neuroinflammatory pathways, including an increased content of interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha (TNF-α), along with reduced levels of IL-10 protein in the spinal cord

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