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1,21−27 The Cu(II) chelation occurs via the glycine amino nitrogen, the deprotonated amide nitrogen of the Gly–His peptide bond, and the His side-chain imidazole nitrogen, yielding two fused chelate rings

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Acetylation The transfer and conjugation of an acetyl group (-COCH 3 ) from the cofactor acetyl coenzyme A (CoA) highlight the acetylation metabolism process