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Figure 3 The p38 MAPK pathway is known to be activated by various environmental stressors, including oxidative stress, hypoxia, UV or ionizing radiation, and osmotic disturbances (130), Additionally, the pathway is stimulated by inflammatory factors such as TNF-α (131, 132), IL-1β (133, 134) and TGF-β (135, 136)) as well as by pathogens including bacterial lipopolysaccharides (LPS) (137), which activate toll-like receptors (TLR)

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