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A phase I clinical trial (NCT03774472) published recently showed that HCQ is safe and well-tolerated and that adding HCQ can enhance the efficacy of low-dose Palbociclib (75 mg/day) and letrozole (2.5 mg/day) therapy in ER+/HER2− metastatic breast cancers [79]

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The continued identification of biomarkers associated with NF1 deficiency in specific cell types should be useful in both devising effective treatments, as well as for assessing whether therapeutic interventions are successful