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Once inside, the Per:Cry complex directly inhibits the transcriptional activity of Bmal1:Clock, thereby forming a classic negative feedback loop that effectively “switches off” their own transcription and clears the way for a new transcriptional cycle to begin [22]
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Kang JH, Hwang SM, Chung IY(2015) S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signalregulated kinase and nuclear factor
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