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In vitro experiments showed that they significantly reduced the viability and proliferation rate of HSFs stimulated by TGF-β1 and downregulated the expression of scar-related genes such as TGF-β1, fibroblast activation protein alpha (FAP-α), and COL1A1, exhibiting local therapeutic effects in both two-dimensional (2D) and 3D cell models ( in vivo model, these patches significantly reduced scar thickness, epidermal thickness index, scar elevation index, the proportion of collagen area, and the number of capillaries in scar tissue

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In one male patient, time to response was not available due to irregular follow-up however, remission status at 1 month was obtained