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Flow regulates various cell activities such as the phosphorylation of proteins like VEGFR-2 and ERK and the orientation and polarity of the cell body ( Future Directions Regarding VEGFR-2 and angiogenesis, further investigation is required to understand how different types of physical forces such as pressure, matrix stiffness, tensile strains, and fluid shear stress affect VEGFR-2 activation and internalization

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Comment: A commenter requested clarity on what “plurality” means within the context of the proposal at § 512.710(d)(1) to only include in the ASM heart failure cohort clinicians with a cardiology specialty code on the plurality of their Medicare Part B claims