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The diagnosis of DRESS syndrome is determined by clinical and laboratory features according to the RegiSCAR validation criteria (Table 2), with the individuation of a causal drug often reinforcing the clinical diagnosis (Table 2) ( The lately published Spanish guidelines for DRESS syndrome suggest using the RegiSCAR criteria for clinical diagnosis ( In patients evaluated for DRESS syndrome, laboratory tests should be performed, including a complete blood count, liver enzymes, blood electrolytes, renal function test, urine analysis, and baseline thyroid function tests ( According to the recent Spanish guidelines ( The clinical severity of DRESS syndrome and the risk of its recurrence could be related to the presence of fever, prolonged leukocytosis, facial edema, lymphadenopathy with erythroderma ( Assessment of the culprit drug of DRESS syndrome is particularly challenging
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