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The inflammatory response involves the release of DAMPS (danger associated molecular patterns): HMGB1, heat-shock, S100 proteins, ATP, which are bound by PRRs (Pattern Recognition Receptors) such as TLR [17]

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Accordingly, Keller and coworkers (63) demonstrated that once RNA is oxidized, protein synthesis significantly decreases over time in primary and the decrease is directly correlated with the oxidation time