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The FAD-dependent pyridine nucleotide disulfide oxidoreductase YpdA (IPR023856) was suggested to function as BSSB reductase because of its phylogenetic relationship to the BSH biosynthesis enzymes as revealed by a STRING search (Gaballa et al., The standard thiol-redox potential of BSH was calculated as E 0′ (BSSB/BSH) = −221 mV which is higher than the GSH redox potential [ E 0′ (GSSG/GSH) = −240 mV] (Sharma et al., 2013)