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However, given the lack of large-scale trials, folic acid supplementation is currently not recommended for cardiovascular disease prevention or treatment, although it may be considered in specific populations, such as those with elevated homocysteine levels (Kaye et al., 2020) or in regions with low dietary folate intake

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Each participating centre fulfilled all regulatory requirements, including IRB-approved protocols, informed consent procedures and data-sharing agreements (Supplementary Note 2)