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This solubility problem is caused by -NH 2 residues on the CH polymeric chain, as when protonated at lower pH levels, it results in diminished dispersion and increased molecular aggregation (Choi et al., 2024)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Zhu Y, Li L, Deng P, Chen X, and Zhong D (2016) Characterization of TPN729 metabolites in humans using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry