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Endotoxins are produced by gram-negative bacteria that were present in the source water and survive ordinary distillation unless the still uses steam distillation at conditions that destroy or carry over no endotoxins

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At the molecular level, experimental autoimmune encephalomyelitis (EAE) mouse models have demonstrated increased expression of iron import proteins (e.g., TfR1) and markers of ferritinophagy (NCOA4), which are correlated with oligodendrocyte death