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Suppression of the malignant phenotype in pancreatic cancer by the overexpression of phospholipid hydroperoxide glutathione peroxidase (PhGPx)

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Conversely, with conditions leading to neurodegeneration or chronic inflammation, oxidative stress persists long enough to lead to abnormal immune response pathways–particularly NF-kb–and prolonged treatment with GSH may lead to reduced redox tone and thus attenuating NF-kB, causing an anti-inflammatory response instead of an immuno-supportive one (Limongi et al., 2019