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Only if the use of an infusional 5-FU regimen is not possible, should a prudent titration of capecitabine doses based on monitoring of toxicity and starting with the recommended reduced dose be considered.” 30 e When two different genetic variants are identified in one patient, they may be located on the same allele or on different alleles

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Citrin deficiency is a specific inherited metabolic disease where high-carbohydrate diet can result in hyperammonemia and require a specific management different from the standard approach described below