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High ranks corresponded to strong Cuprizone-induced reactions (i.e., low PLP immunoreactivity, high IBA1 or GFAP immunoreactivity, high body-weight loss and high density of APP-positive spheroids)

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RNA quantity and quality (260/280 and 260/230 ratio) was measured by a MaestroNano Spectrophotometer (Maestrogen, Taiwan) and RNA degradation was also checked by formaldehyde agarose gel electrophoresis of total RNA