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Key Points The insulin-like growth factor 1 ( IGF1 ) gene is a major target of growth hormone IGF1 binds the IGF1 receptor (IGF1R) with high affinity and the insulin receptor with low affinity
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At the translational level, rigorous evaluation of the long-term efficacy and safety of selective receptor modulators (SERMs, SPRMs), aromatase inhibitors, and their combination with antioxidant therapies is essential
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