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furthermore, an expansion of synovial fibroblasts and macrophage-like cells leads to the proliferation of the supra-synovial layer and invasion of the periarticular bone at the cartilage junction, ultimately leading to bone erosion and cartilage degeneration ( The GABAergic system is a network of neurons in the brain and central nervous system that produce and use the neurotransmitter GABA ( GABAergic system The GABAergic system comprises the following components: GABA, glutamate decarboxylase (GAD), GABA-A receptors, GABA-B receptors, and GABA transporters (GATs)