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Another study found a link between VEGF and Nrf2 activation, demonstrating that VEGF increased Nrf2 expression in an ERK1/2-dependent manner (Kweider et al., 2011)

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The GH-type fluid-retention syndrome — sustained edema, carpal tunnel compression, joint stiffness — is IGF-1- and GH-mediated, and would not be expected from a compound that does not raise either