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Recent work has expanded this heterogeneity concept to brown, beige, and ectopic fat, with each depot’s molecular profile differently impacting systemic metabolism (390, 391)
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The KIF20A-NUAK1-PP1β-GPX4 signaling pathway can directly or indirectly inhibit ferroptosis in colorectal cancer cells, 45 playing an important role in reversing colorectal cancer resistance to oxaliplatin
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