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In the TME, excessive ammonia accumulation triggers endoplasmic reticulum (ER) stress, activating ER stress sensors such as IRE1 and PERK

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Finally, melatonin repairs oxidatively damaged DNA which aids in preventing mutations (164–166) and it also inhibits telomerase which counteracts the shortening of telomeres, hexameric tandem repeats, on linear chromosomes during cell replication or during certain pathological processes (167)