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STIM1 oligomerizes upon Ca 2+ store depletion and distributes into a punctate pattern in parts of the ER that are apposed to the plasma membrane, where it presumably interacts, directly or indirectly, with ORAI1-containing CRAC channels

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The accumulation of macrophages and rejection macrophages has long been considered a characteristic of allograft rejection, with the total number of graft-infiltrating macrophages being associated with poorer clinical outcomes (254)