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Discovery of a covalent inhibitor of KRAS(G12C) (AMG 510) for the treatment of solid tumors

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The factors studied were as follows with TaqMan Gene Expression Assay primer IDs in parentheses : VEGF (Mm01281449_m1), HGF (Mm01135193_m1), TGFb1 (Mm01178820_m1), HIF1a (Mm00468869_m1), FGF1 (Mm00438906_m1), ANGPT1 (Mm00456503_m1), ANGPT2 (Mm00545822_m1), ANGPTL1 (Mm01291815_m1), ANGPTL2 (Mm00507897_m1), PAI1 (Mm00435860_m1), CSF2 (Mm01290062_m1), CSF3 (Mm00438335_g1), CXCL2 (Mm00436450_m1), MMP9 (Mm00442991_m1), and TNMD (Mm00491594_m1)