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Key design decisions influenced by the Phase 2 results include the selection of dose levels, the implementation of slower dose-escalation schedules to improve tolerability and reduce discontinuations, the focus on F2-F3 fibrosis (where the Phase 2 signal was strongest), and the inclusion of long-term clinical liver outcome endpoints to assess whether histological improvements translate into reductions in liver-related morbidity and mortality

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I felt stronger and more energetic within days." Mark H