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Mechanism of Action: How They Differ The core distinction between AOD-9604 vs Retatrutide (GLP-3 RT) comes down to scope: AOD-9604 acts on a single, localized fat metabolism pathway, while GLP-3 RT works systemically across three separate receptor systems at once

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BA physiology is diversely altered in Insr P1195L/ + /HFD mice P1195L/ + As fat-specific insulin receptor deficient mice (FIRKO mice) failed to exhibit glucose intolerance, we examined the contribution of insulin resistance in liver