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The role of oxidative stress during inflammatory processes

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Importantly, whereas the predominant redox roles of GSH involve considerable recycling between the reduced GSH and oxidized GSSG forms, other often major roles for GSH, including hepatic export of GSSG as a systemic source of amino acids for intermediary metabolism and many GSH-S-transferase (GST)-catalyzed conjugation activities involved in detoxification reactions, result in loss of GSH from the cell