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These compounds attenuate systemic inflammation by lowering circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), biomarkers consistently associated with endothelial dysfunction [124]

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376 The potential impairment of mitochondrial transfer and transport due to OPA1 mutations should be considered as a contributing factor to the vulnerability of RGCs