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The IRE1α pathway activates JNK signaling, promoting inflammatory cytokine production and exacerbating insulin resistance (Su et al., 2013)

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612 NMN treatment improves the neuronal functions, including rescuing the memory and cognition in rodent models for Alzheimer’s disease, protecting neurons from cell death after intracerebral hemorrhage or ischemia, recovering severe retinal degeneration and restoring the age-associated loss of the neural stem/progenitor pool