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The vitamin B12 biosynthesis pathway in the skin bacterium, Propionibacterium acnes , was significantly down-regulated in acne patients

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In a randomized DBPC 3-month study of 20 children with ASD (ages 3–8 yo), a MVI, which also contained 1200–1600 mcg of oral cB12, led to significant improvements in sleep and gastrointestinal problems compared to placebo [48]