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Several other studies point towards a crucial role for D2 (and D3, see below) in regulating local T3 concentrations, and as a consequence it is know well accepted that these deiodinases can regulate thyroid hormone action at the cellular level during development and tissue stress relatively independent of serum T4 and T3 concentrations (3)
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doi: 10.1016/j.bbapap.2008.07.016
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