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These effects arise directly from the covalent interaction of cisplatin (and carboplatin) with DNA purine residues, as well as indirectly from drug-triggered increases in oxidative stress once endogenous scavenging defenses become engaged in adduct formation

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Anxiolytics may temporarily improve symptoms, with benzodiazepines likely to provide the most benefit.4 Clonazepam is often preferred due to its longer half-life