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[105] These procedures are usually performed on an outpatient basis under local anesthesia or light sedation and allow quicker recovery with reduced risk of complications: [106] Enucleation techniques: Holmium laser enucleation of the prostate (HoLEP): performed using a Holmium:YAG laser [107] Thulium laser enucleation of the prostate (ThuLEP): performed using a Thulium:YAG laser or, increasingly, a Thulium fiber laser (TFL) [108] Both HoLEP and ThuLEP are endoscopic enucleation techniques in which prostatic adenoma tissue is dissected (“shelled out”) from the surgical capsule and subsequently removed

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Where LR3 appears in this literature it is usually as a convenient binding-protein-resistant tool for showing that an effect attributed to IGF-1 is not simply an effect on binding-protein availability, which is a legitimate and rather elegant use of it