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In this context, research strategies aimed at the selective inhibition of FOXO proteins – including the use of peptide analogs such as FOXO4-DRI – represent a promising approach for investigating the modulation of metabolic pathways, with potential relevance to diabetes-related complications

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observed that monocytes isolated from CF heterozygotes, when stimulated with concanavalin A, exhibited a significantly higher release of superoxide compared to monocytes from healthy controls after a 3-min measurement period