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This suggested a pathway in which d-galacturonic acid, generated from the breakdown of pectin in the ripening fruit, is reduced to l-galactonic acid through the action of an NADPH-dependent d-galacturonic acid reductase (GalUR), and the l-galactonic acid then spontaneously converts to l-galactono-1,4 lactone [32] (Figure 1)

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Overexpression of anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL) or silencing of pro-apoptotic members (e.g., Bax, Bad) shifts the mitochondrial balance toward cell survival