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Pharmacological antagonist studies directly confirmed this split: blocking the GHRP-like receptor abolishes ipamorelin’s GH-releasing effect without affecting the GHRH pathway, thereby establishing that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor rather than through GHRH-receptor activation

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Together, these results indicate that the abundance of mitochondrial CI is regulated by the circadian clock independently of direct transcriptional control