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SFN treatment also reduced the activation of STAT3 and NF-κB pathways and downregulated pro-inflammatory cytokines IL-1β, IL-6, and CCL2
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The administration of a synthetic peptide (FOXO4-DRI = FOXO4-D-Retro-Inverso) to avoid the interaction between FOXO4 and p53 leads to a decrease of irradiated-induced senescent fibroblasts viability
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