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Activation of death receptors leads to formation of the death-inducing signaling complex, which includes the Fas-associated death domain (FADD), initiator caspase 8 or 10, and the cellular FADD-like interleukin-1 beta-converting enzyme (FLICE)-inhibitory protein (FLIP) leading to the activation of initiator caspases

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Formalin induces biphasic activity in C-fibers in the rat