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A decrease in NTx levels has been show to correlate to a decrease in osteoclast activity, and thus a decrease in bone breakdown [10] which means there is less bone for the osteoblastic bone formation to replace

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Longitudinal data from Cardiff, Wales (1931–2008) demonstrated a steady increase in CD incidence, with rates nearly doubling each decade from 1.17 (1946–1955) to 7.09 (1976–1985), before levelling off at 5.88 (1986–1995) and 6.64 (1996–2005) 10 (Supplementary Fig