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We took advantage of in vitro reprogramming systems, including doxycycline-free viral reprogramming, to directly demonstrate the limiting, cell-intrinsic role of B 12 in this process

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A complete CoA should list HPLC (High-Performance Liquid Chromatography) for purity quantification, mass spectrometry (ESI-MS or MALDI-TOF) for molecular identity confirmation, and ideally NMR spectroscopy for structural validation