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ROS can directly be involved in carcinogenesis through oxidation, halogenation, and nitration of nuclear DNA, lipids and ribonucleic acid (RNA) (216),indirectly by the activation of different signalling pathways ( Figure 8 ) (217, 218)
Health Goals_General Wellness
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This initial recognition not only triggers epithelial cell-autonomous responses (e.g., barrier reinforcement, secretion of proinflammatory cytokines) but also primes the subsequent recruitment and activation of innate immune cells
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