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What Milos pointed out was that during resistance exercise, you can take advantage of hyperemia—the increase in blood flow to skeletal muscle—to maximize the delivery of nutrients into the bloodstream with intra-workout supplementation (literally, taking sips from your shaker cup between sets)

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After 8 weeks, the treatment group showed a 20% increase in hydration levels, measured by corneometry, and improved epidermal and dermal thickness due to enhanced glycosaminoglycan synthesis (Krüger et al., 2010)