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reported the importance of oxidoreductase-like protein Olp1 in Cryptococcus neoformans for sexual reproduction through enhancing the meiotic division and its essential role in the pathogenicity by protecting the fungal cells from lithium–ion toxicity [60]

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Although emerging evidence has aided the understanding of pharmacokinetic mechanisms, the true impact of reduced kidney function on pharmacokinetics, along with pharmacodynamic mechanisms of commonly used anticancer agents, remains unclear and poorly evaluated, with substantial uncertainty surrounding the potential clinical implications for patients with AKD or CKD and cancer (Table 4 and Supplementary Table 6)