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Interestingly, this NO diffusion also conferred ferroptosis resistance to surrounding cells near M1 macrophages, mimicking the protective effect of Glutathione peroxidase 4 (GPX4)

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It, therefore, seems quite likely that contraction-induced ROS-S activates AMPK by oxidation, thus mediating the enhanced glucose uptake, and could partly account for poor results obtained for supposed ‘muscle supplementation’ with antioxidants