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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Younossi Z.M., Paik J.M., Stepanova M., Ong J., Alqahtani S., Henry L

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Deletion of Mat1a gene in mice promotes chronic SAMe reduction in the liver, that leads to hepatic hyperplasia at 3 months of age, intrahepatic fat accumulation, MASH and fibrosis at 8 months and, spontaneous HCC by 18 months of age [68,69,80,100]