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Recent studies have found that GSK3β promotes the expression of apoptosis inhibitor of macrophage (AIM) in macrophages through transcriptional activity of STAT3, leading to inflammation in visceral adipose tissue during obesity [59], and regulates WAT vascularization and metabolic disorders through AMPK-mediated modulation of HIF-2α [60]

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MR is a method that integrates epidemiology and genetics, utilizing naturally occurring genetic variations to simulate randomized experiments for causal inference, thereby more accurately estimating the influence of specific factors on outcomes (24, 25)