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In this context, it is plausible to consider A1AT as a protective host factor against COVID-19, not only decreasing SARS-CoV-2 entry, but also protecting from the main clinical complications, such as acute inflammation and acute respiratory insufficiency ( Figure 3 3 Conclusion Considering the cumulative evidence supporting the beneficial effects of A1AT in chronic inflammatory diseases, it is important to conduct comprehensive clinical studies to ascertain its true clinical efficacy in patient populations affected by each specific disease